SCHEMBL8419930

SCHEMBL8419930

CC(C)(C)Nc1c(NCc2cc3cc([N+](=O)[O-])ccc3o2)c(=O)c1=O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.44
CA9 Q16790 2/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
MAOB P27338 7/20 0.42
MAOA P21397 4/20 0.42
POLB P06746 2/20 0.41
XDH P47989 1/20 0.40
F12 P00748 1/20 0.39
KMT2A Q03164 3/20 0.39
MEN1 O00255 2/20 0.39
HRH3 Q9Y5N1 1/20 0.38
PKM P14618 1/20 0.38
ACHE P22303 1/20 0.38
PPARG P37231 1/20 0.38
PPARA Q07869 1/20 0.38
LMNA P02545 1/20 0.37
GAA P10253 1/20 0.37
MAPT P10636 1/20 0.37
HPGD P15428 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8423519 0.90 MAOB (0.41) CA12CA9CA1CA2MAOB
SCHEMBL8420707 0.85 MAOB (0.43) CA12CA9CA1CA2MAOB
SCHEMBL8384333 0.78 XDH (0.41) CA12CA9CA1CA2MAOB
SCHEMBL5711170 0.73 CA12 (0.54) CA12CA9CA1CA2MAOB
SCHEMBL8386573 0.71 HRH3 (0.39) HRH3
SCHEMBL8178252 0.71 CA12 (0.51) CA12CA9CA1CA2MAOB
SCHEMBL8381918 0.70 MAOB (0.51) CA12CA9CA1CA2MAOB
SCHEMBL27922627 0.70 MAOB (0.51) CA12CA9CA1CA2MAOB
SCHEMBL4013115 0.70 MAOB (0.55) CA12CA9CA1CA2MAOB
SCHEMBL8420073 0.70 CA12 (0.54) CA12CA9CA1CA2MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0906282-A1 HETEROCYCLYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AS POTASSIUM CHANNEL MODULATORS AMERICAN HOME PRODUCTS CORPORATION (US) 1999-04-07 EP claimed
US-5872139-A MUSCLE RELAXANTS USED TO TREAT URINARY INCONTINENCE, IRRITABLE BOWEL SYNDROME, ASTHMA, PREMATURE LABOR, CONGESTIVE HEART FAILURE, ANGINA, CEREBRAL VASCULAR DISEASE AND HYPERTENSION AMERICAN HOME PRODUCTS CORPORATION (US) 1999-02-16 US claimed
WO-1997048682-A1 HETEROCYCLYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AS POTASSIUM CHANNEL MODULATORS AMERICAN HOME PRODUCTS CORPORATION (US) 1997-12-24 WO claimed
EP-0906282-A1 HETEROCYCLYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AS POTASSIUM CHANNEL MODULATORS AMERICAN HOME PRODUCTS CORPORATION (US) 1999-04-07 EP disclosed
US-5872139-A MUSCLE RELAXANTS USED TO TREAT URINARY INCONTINENCE, IRRITABLE BOWEL SYNDROME, ASTHMA, PREMATURE LABOR, CONGESTIVE HEART FAILURE, ANGINA, CEREBRAL VASCULAR DISEASE AND HYPERTENSION AMERICAN HOME PRODUCTS CORPORATION (US) 1999-02-16 US disclosed
WO-1997048682-A1 HETEROCYCLYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AS POTASSIUM CHANNEL MODULATORS AMERICAN HOME PRODUCTS CORPORATION (US) 1997-12-24 WO disclosed