SCHEMBL8420707

SCHEMBL8420707

CC(Nc1c(NCc2cc3cc([N+](=O)[O-])ccc3o2)c(=O)c1=O)C(C)(C)C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 4/20 0.43
MAOA P21397 2/20 0.43
CA12 O43570 2/20 0.41
CA9 Q16790 2/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
POLB P06746 1/20 0.38
XDH P47989 1/20 0.38
ALDH1A1 P00352 1/20 0.37
CASP3 P42574 1/20 0.37
CASP7 P55210 1/20 0.37
PLK1 P53350 3/20 0.37
F12 P00748 1/20 0.36
ABCC9 O60706 1/20 0.36
ABCC8 Q09428 1/20 0.36
KCNJ11 Q14654 1/20 0.36
KCNJ8 Q15842 1/20 0.36
HRH3 Q9Y5N1 1/20 0.36
KMT2A Q03164 2/20 0.36
MEN1 O00255 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8419930 0.85 CA12 (0.44) MAOBMAOACA12CA9CA1
SCHEMBL8420168 0.82 ABCC9 (0.53) PLK1ABCC9ABCC8KCNJ11KCNJ8
SCHEMBL8423519 0.82 MAOB (0.41) MAOBMAOACA12CA9CA1
SCHEMBL8384333 0.74 XDH (0.41) MAOBMAOACA12CA9CA1
SCHEMBL8178252 0.70 CA12 (0.51) MAOBMAOACA12CA9CA1
SCHEMBL5711170 0.70 CA12 (0.54) MAOBMAOACA12CA9CA1
SCHEMBL8420710 0.69 CA12 (0.41) MAOBMAOACA12CA9CA1
SCHEMBL8381918 0.67 MAOB (0.51) MAOBMAOACA12CA9CA1
SCHEMBL4013115 0.67 MAOB (0.55) MAOBMAOACA12CA9CA1
SCHEMBL27922627 0.67 MAOB (0.51) MAOBMAOACA12CA9CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5872139-A MUSCLE RELAXANTS USED TO TREAT URINARY INCONTINENCE, IRRITABLE BOWEL SYNDROME, ASTHMA, PREMATURE LABOR, CONGESTIVE HEART FAILURE, ANGINA, CEREBRAL VASCULAR DISEASE AND HYPERTENSION AMERICAN HOME PRODUCTS CORPORATION (US) 1999-02-16 US claimed
EP-0906282-A1 HETEROCYCLYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AS POTASSIUM CHANNEL MODULATORS AMERICAN HOME PRODUCTS CORPORATION (US) 1999-04-07 EP disclosed
US-5872139-A MUSCLE RELAXANTS USED TO TREAT URINARY INCONTINENCE, IRRITABLE BOWEL SYNDROME, ASTHMA, PREMATURE LABOR, CONGESTIVE HEART FAILURE, ANGINA, CEREBRAL VASCULAR DISEASE AND HYPERTENSION AMERICAN HOME PRODUCTS CORPORATION (US) 1999-02-16 US disclosed
WO-1997048682-A1 HETEROCYCLYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AS POTASSIUM CHANNEL MODULATORS AMERICAN HOME PRODUCTS CORPORATION (US) 1997-12-24 WO disclosed