Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | ACLY | P53396 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8420193 | 0.99 | MCL1 (0.39) | ALDH1A1LMNAMCL1BCL2A1SLC22A12 | |
| SCHEMBL8419412 | 0.84 | ALDH1A1 (0.43) | ALDH1A1LMNAMCL1BCL2A1SLC22A12 | |
| SCHEMBL8420946 | 0.84 | EDNRA (0.45) | ALDH1A1MCL1BCL2A1SLC22A12MEN1 | |
| SCHEMBL8419749 | 0.83 | EDNRA (0.44) | MCL1BCL2A1MEN1KMT2APIK3CA | |
| SCHEMBL8423223 | 0.83 | PIK3CA (0.46) | ALDH1A1SLC22A12MEN1GAAKMT2A | |
| SCHEMBL8421498 | 0.83 | ALDH1A1 (0.44) | ALDH1A1LMNASLC22A12MEN1KMT2A | |
| SCHEMBL8421220 | 0.82 | EDNRA (0.45) | MCL1BCL2A1SLC22A12MEN1KMT2A | |
| SCHEMBL8423226 | 0.81 | ALDH1A1 (0.48) | ALDH1A1LMNAMCL1MEN1KMT2A | |
| SCHEMBL8419444 | 0.80 | EDNRA (0.43) | SLC22A12MEN1KMT2ASCN9AACLY | |
| SCHEMBL8421510 | 0.80 | SLC22A12 (0.39) | ALDH1A1LMNASLC22A12MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5916905-A | ANTIARTHRITIC AGENTS; ANALGESICS; ANTIPYRETICS | G. D. SEARLE & CO. (US) | 1999-06-29 | — | — | US | disclosed |
| US-5686470-A | 2, 3-substituted pyridines for the treatment of inflammation | WEIER RICHARD M (US) | 1997-11-11 | — | — | US | disclosed |