SCHEMBL8420236

SCHEMBL8420236

CCSC1=NCC(=O)N1c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.48
ALOX12 P18054 1/20 0.48
SMN1; SMN2 Q16637 3/20 0.44
KDM4E B2RXH2 3/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
LMNA P02545 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
HTT P42858 1/20 0.43
CYP2C19 P33261 4/20 0.43
CYP1A2 P05177 2/20 0.43
CYP3A4 P08684 2/20 0.43
CYP2C9 P11712 2/20 0.43
CYP2D6 P10635 1/20 0.43
MAPT P10636 2/20 0.41
MAPK1 P28482 1/20 0.41
PDE7A Q13946 1/20 0.41
PPARG P37231 1/20 0.41
BLM P54132 1/20 0.41
NCOA2 Q15596 1/20 0.41
NCOA1 Q15788 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8419888 0.86 KMT2A (0.45) ALDH1A1ALOX12SMN1; SMN2KDM4ECYP2C19
SCHEMBL8420005 0.82 MAPT (0.46) ALDH1A1ALOX12SMN1; SMN2KDM4EL3MBTL1
SCHEMBL8421478 0.81 ALDH1A1 (0.42) ALDH1A1SMN1; SMN2L3MBTL1HTTCYP2C19
SCHEMBL8419710 0.80 MEN1 (0.40) ALDH1A1ALOX12SMN1; SMN2L3MBTL1PDE7A
SCHEMBL8421298 0.79 ALDH1A1 (0.40) ALDH1A1ALOX12SMN1; SMN2L3MBTL1HTT
SCHEMBL8419705 0.75 CHRNA7 (0.39) ALDH1A1SMN1; SMN2L3MBTL1LMNAHTT
SCHEMBL8421825 0.75 GAA (0.45) ALDH1A1KDM4EL3MBTL1LMNAHTT
SCHEMBL8419753 0.73 ALDH1A1 (0.41) ALDH1A1SMN1; SMN2LMNAMAPTNPSR1
SCHEMBL8419733 0.72 HTR7 (0.41) ALDH1A1ALOX12SMN1; SMN2MAPTNPSR1
SCHEMBL15203010 0.70 CDC25A (0.53) ALDH1A1SMN1; SMN2KDM4EL3MBTL1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5877324-A ANTICHOLESTEROL AGENT AMERICAN HOME PRODUCTS CORPORATION (US) 1999-03-02 US claimed
EP-0876354-A1 2-(SUBSTITUTED SULFANYL)-3,5-DIHYDRO-IMIDAZOL-4-ONE DERIVATIVES AMERICAN HOME PRODUCTS CORPORATION (US) 1998-11-11 EP claimed
WO-1997019931-A1 2-(SUBSTITUTED SULFANYL)-3,5-DIHYDRO-IMIDAZOL-4-ONE DERIVATIVES AMERICAN HOME PRODUCTS CORPORATION (US) 1997-06-05 WO claimed
US-5599829-A FOR INCREASED HIGH DENSITY LIPOPROTEIN LEVELS IN BLOOD AMERICAN HOME PRODUCTS CORPORATION (US) 1997-02-04 US claimed
US-5877324-A ANTICHOLESTEROL AGENT AMERICAN HOME PRODUCTS CORPORATION (US) 1999-03-02 US disclosed
EP-0876354-A1 2-(SUBSTITUTED SULFANYL)-3,5-DIHYDRO-IMIDAZOL-4-ONE DERIVATIVES AMERICAN HOME PRODUCTS CORPORATION (US) 1998-11-11 EP disclosed
WO-1997019931-A1 2-(SUBSTITUTED SULFANYL)-3,5-DIHYDRO-IMIDAZOL-4-ONE DERIVATIVES AMERICAN HOME PRODUCTS CORPORATION (US) 1997-06-05 WO disclosed
US-5599829-A FOR INCREASED HIGH DENSITY LIPOPROTEIN LEVELS IN BLOOD AMERICAN HOME PRODUCTS CORPORATION (US) 1997-02-04 US disclosed