Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | LTB4R | Q15722 | 8/20 | 0.49 |
| ▸ | LTB4R2 | Q9NPC1 | 8/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | KLK14 | Q9P0G3 | 1/20 | 0.39 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8571699 | 0.87 | LTB4R (0.52) | ALDH1A1LTB4RLTB4R2KDM4EAPP | |
| SCHEMBL8569978 | 0.87 | LTB4R (0.52) | ALDH1A1LTB4RLTB4R2KDM4EAPP | |
| SCHEMBL8420169 | 0.87 | LTB4R (0.52) | ALDH1A1LTB4RLTB4R2KDM4EAPP | |
| SCHEMBL7976412 | 0.80 | LTB4R (0.75) | LTB4RLTB4R2 | |
| SCHEMBL7976408 | 0.80 | LTB4R (0.75) | LTB4RLTB4R2 | |
| SCHEMBL7976417 | 0.80 | LTB4R (0.75) | LTB4RLTB4R2 | |
| SCHEMBL8422495 | 0.80 | LTB4R (0.52) | ALDH1A1LTB4RLTB4R2KDM4EAPP | |
| SCHEMBL8418885 | 0.79 | LTB4R (0.65) | ALDH1A1LTB4RLTB4R2KDM4EAPP | |
| SCHEMBL8564500 | 0.79 | LTB4R (0.65) | ALDH1A1LTB4RLTB4R2KDM4EAPP | |
| SCHEMBL8418430 | 0.79 | LTB4R (0.52) | ALDH1A1LTB4RLTB4R2KDM4EAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | disclosed |