Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.62 |
| ▸ | RARA | P10276 | 5/20 | 0.58 |
| ▸ | RARB | P10826 | 5/20 | 0.58 |
| ▸ | RARG | P13631 | 5/20 | 0.58 |
| ▸ | RXRA | P19793 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9253143 | 0.91 | PTGS2 (0.66) | PTGS2SMN1; SMN2PTGS1CA12CA1 | |
| SCHEMBL8422302 | 0.90 | PTGS2 (0.70) | PTGS2RARARARBRARGRXRA | |
| SCHEMBL8420932 | 0.90 | PTGS2 (0.59) | PTGS2RARARARBRARGRXRA | |
| SCHEMBL9038810 | 0.89 | RARG (0.69) | PTGS2RARARARBRARGRXRA | |
| SCHEMBL8126446 | 0.89 | SMN1; SMN2 (0.70) | PTGS2SMN1; SMN2PTGS1CA12CA1 | |
| SCHEMBL9049040 | 0.86 | PTGS2 (0.67) | PTGS2RARARARBRARGRXRA | |
| SCHEMBL8423820 | 0.85 | PTGS2 (0.73) | PTGS2RARARARBRARGRXRA | |
| SCHEMBL8422372 | 0.84 | PTGS2 (0.67) | PTGS2RARARARBRARGRXRA | |
| SCHEMBL8423800 | 0.84 | PTGS2 (0.69) | PTGS2RARARARBRARGRXRA | |
| SCHEMBL9039158 | 0.83 | PTGS2 (0.62) | PTGS2RARARARBRARGRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908852-A | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation | G. D. SEARLE & CO. (US) | 1999-06-01 | — | — | US | disclosed |
| EP-0731796-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-09-18 | — | — | EP | disclosed |
| US-5434178-A | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation | G.D. SEARLE & CO. (US) | 1995-07-18 | — | — | US | disclosed |
| WO-1995015318-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-06-08 | — | — | WO | disclosed |