SCHEMBL8423441

SCHEMBL8423441

N=C(N)Nc1ccc(C[C@H](N)C(=O)O)s1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 4/20 0.40
NOS1 P29475 4/20 0.40
NOS2 P35228 4/20 0.40
SLC7A5 Q01650 3/20 0.40
PKM P14618 2/20 0.40
PTGS1 P23219 2/20 0.40
ALPI P09923 1/20 0.40
XIAP P98170 1/20 0.40
USP2 O75604 3/20 0.37
HSD17B10 Q99714 3/20 0.37
HIF1A Q16665 3/20 0.37
KDM4E B2RXH2 3/20 0.37
ALOX15 P16050 2/20 0.37
RECQL P46063 2/20 0.37
TDP1 Q9NUW8 2/20 0.37
MEN1 O00255 2/20 0.37
ALDH1A1 P00352 2/20 0.37
LMNA P02545 2/20 0.37
MAPT P10636 2/20 0.37
HPGD P15428 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8423444 1.00 NOS3 (0.40) NOS3NOS1NOS2SLC7A5PKM
SCHEMBL8520165 0.87 SLC7A5 (0.42) NOS3NOS1NOS2SLC7A5PKM
SCHEMBL8609791 0.87 SLC7A5 (0.42) NOS3NOS1NOS2SLC7A5PKM
SCHEMBL8425394 0.82 NOS3 (0.59) NOS3NOS1NOS2SLC7A5PKM
SCHEMBL9172559 0.79 SLC7A5 (0.55) NOS3NOS1NOS2SLC7A5PKM
SCHEMBL8423549 0.78 NOS3 (0.40) NOS3NOS1NOS2SLC7A5PKM
SCHEMBL8609795 0.77 SLC7A5 (0.38) NOS3NOS1NOS2SLC7A5PKM
SCHEMBL8425902 0.77 NOS3 (0.39) NOS3NOS1NOS2SLC7A5PKM
SCHEMBL8526061 0.74 ACE (0.45)
Hydrochloric Acid SCHEMBL4684147 0.73 DAO (0.42) PKMHSD17B10KDM4EALOX15TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5874472-A Aminoacid derivatives as no synthase inhibitors GLAXO WELLCOME INC. (US) 1999-02-23 US claimed
EP-0705257-B1 AMINOACID DERIVATIVES AS NO SYNTHASE INHIBITORS WELLCOME FOUND (GB) 1998-03-11 EP claimed
EP-0705257-A1 AMINOACID DERIVATIVES AS NO SYNTHASE INHIBITORS THE WELLCOME FOUNDATION LIMITED (GB) 1996-04-10 EP claimed
WO-1995000505-A1 AMINOACID DERIVATIVES AS NO SYNTHASE INHIBITORS THE WELLCOME FOUNDATION LIMITED (GB) 1995-01-05 WO claimed
US-5874472-A Aminoacid derivatives as no synthase inhibitors GLAXO WELLCOME INC. (US) 1999-02-23 US disclosed
EP-0705257-B1 AMINOACID DERIVATIVES AS NO SYNTHASE INHIBITORS WELLCOME FOUND (GB) 1998-03-11 EP disclosed
EP-0705257-A1 AMINOACID DERIVATIVES AS NO SYNTHASE INHIBITORS THE WELLCOME FOUNDATION LIMITED (GB) 1996-04-10 EP disclosed
WO-1995000505-A1 AMINOACID DERIVATIVES AS NO SYNTHASE INHIBITORS THE WELLCOME FOUNDATION LIMITED (GB) 1995-01-05 WO disclosed