SCHEMBL8423451

SCHEMBL8423451

CCCC(=O)NNC(C)=O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 3/20 0.52
HDAC1 Q13547 3/20 0.52
HDAC2 Q92769 3/20 0.52
HDAC8 Q9BY41 3/20 0.52
HDAC6 Q9UBN7 1/20 0.52
MAPT P10636 3/20 0.50
KMT2A Q03164 2/20 0.50
MEN1 O00255 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
CTSD P07339 1/20 0.50
KDM4E B2RXH2 2/20 0.47
CYP2C19 P33261 2/20 0.46
ALDH1A1 P00352 2/20 0.46
RECQL P46063 1/20 0.46
ALOX5 P09917 1/20 0.45
CYP3A4 P08684 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
MAPK1 P28482 1/20 0.44
HTT P42858 1/20 0.42
CASP2 P42575 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6634673 0.89 HDAC3 (0.63) HDAC3HDAC1HDAC2HDAC8HDAC6
SCHEMBL3933329 0.83 KMT2A (0.67) MAPTKMT2AMEN1NPSR1KDM4E
SCHEMBL8745827 0.81 KMT2A (0.65) MAPTKMT2AMEN1NPSR1KDM4E
SCHEMBL6025729 0.81 HDAC3 (0.55) HDAC3HDAC1HDAC2HDAC8HDAC6
SCHEMBL12155314 0.81 KMT2A (0.53) HDAC3HDAC1HDAC2HDAC8HDAC6
SCHEMBL29039505 0.79 HDAC3 (0.52) HDAC3HDAC1HDAC2HDAC8HDAC6
SCHEMBL9117059 0.79 HDAC3 (0.52) HDAC3HDAC1HDAC2HDAC8HDAC6
SCHEMBL10520278 0.79 CTSD (0.56) HDAC3HDAC1HDAC2HDAC8HDAC6
SCHEMBL29092803 0.79 MAPT (0.73) HDAC3HDAC1HDAC2HDAC8HDAC6
SCHEMBL12584010 0.79 NAAA (0.39) MAPTKMT2AMEN1NPSR1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0948523-A1 PEPTIDOMIMETIC INHIBITORS OF THE HUMAN CYTOMEGALOVIRUS PROTEASE BOEHRINGER INGELHEIM (CANADA) LTD. (CA) 1999-10-13 EP claimed
WO-1998029435-A1 PEPTIDOMIMETIC INHIBITORS OF THE HUMAN CYTOMEGALOVIRUS PROTEASE BOEHRINGER INGELHEIM (CANADA) LTD. (CA) 1998-07-09 WO claimed
EP-0948523-A1 PEPTIDOMIMETIC INHIBITORS OF THE HUMAN CYTOMEGALOVIRUS PROTEASE BOEHRINGER INGELHEIM (CANADA) LTD. (CA) 1999-10-13 EP disclosed
WO-1998029435-A1 PEPTIDOMIMETIC INHIBITORS OF THE HUMAN CYTOMEGALOVIRUS PROTEASE BOEHRINGER INGELHEIM (CANADA) LTD. (CA) 1998-07-09 WO disclosed
US-4985043-A Mixtures of monoazo dyes containing halogen and cyano substituents CASSELLA AKTIENGESELLSCHAFT (DE) 1991-01-15 US disclosed