Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 10/20 | 0.65 |
| ▸ | AR | P10275 | 10/20 | 0.65 |
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.65 |
| ▸ | ESR1 | P03372 | 2/20 | 0.65 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.65 |
| ▸ | NR3C2 | P08235 | 5/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.52 |
| ▸ | SHBG | P04278 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8427015 | 0.91 | PGR (0.64) | PGRARLMNASLC6A4ESR1 | |
| SCHEMBL8426985 | 0.85 | PGR (0.54) | PGRARLMNASLC6A4ESR1 | |
| SCHEMBL8678004 | 0.83 | PGR (0.76) | PGRARLMNASLC6A4ESR1 | |
| SCHEMBL12434544 | 0.82 | PGR (0.74) | PGRARLMNASLC6A4ESR1 | |
| Gestodene SCHEMBL2335657 | 0.79 | PGR (1.00) | PGRARLMNASLC6A4ESR1 | |
| Gestodene SCHEMBL5031715 | 0.79 | PGR (1.00) | PGRARLMNASLC6A4ESR1 | |
| Gestodene SCHEMBL15263394 | 0.79 | PGR (1.00) | PGRARLMNASLC6A4ESR1 | |
| Gestodene SCHEMBL16661464 | 0.79 | PGR (1.00) | PGRARLMNASLC6A4ESR1 | |
| Gestodene SCHEMBL1650027 | 0.79 | PGR (1.00) | PGRARLMNASLC6A4ESR1 | |
| Gestodene SCHEMBL14983004 | 0.79 | PGR (1.00) | PGRARLMNASLC6A4ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0582338-B1 | 17-Spiromethylene steroids | AKZO NOBEL NV (NL) | 1999-10-20 | — | — | EP | disclosed |
| EP-0582338-A2 | 17-Spiromethylene steroids | Akzo Nobel N.V. (NL) | 1994-02-09 | — | — | EP | disclosed |