Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 7/20 | 0.54 |
| ▸ | AR | P10275 | 6/20 | 0.54 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | ESR1 | P03372 | 2/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SHBG | P04278 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.47 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8423652 | 0.90 | PGR (0.53) | PGRARNR3C2CYP19A1LMNA | |
| SCHEMBL8423660 | 0.85 | PGR (0.65) | PGRARNR3C2CYP19A1LMNA | |
| SCHEMBL9541199 | 0.83 | PGR (0.58) | PGRARNR3C2CYP19A1LMNA | |
| SCHEMBL8427015 | 0.79 | PGR (0.64) | PGRARNR3C2CYP19A1LMNA | |
| SCHEMBL8425076 | 0.77 | PGR (0.64) | PGRARNR3C2CYP19A1LMNA | |
| SCHEMBL9007371 | 0.76 | PGR (0.56) | PGRARNR3C2CYP19A1LMNA | |
| SCHEMBL9007368 | 0.76 | PGR (0.56) | PGRARNR3C2CYP19A1LMNA | |
| SCHEMBL8427312 | 0.75 | PGR (0.44) | PGRARNR3C2CYP19A1LMNA | |
| SCHEMBL13160889 | 0.73 | PGR (0.67) | PGRARNR3C2CYP19A1LMNA | |
| SCHEMBL11942939 | 0.73 | PGR (0.67) | PGRARNR3C2CYP19A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0582338-B1 | 17-Spiromethylene steroids | AKZO NOBEL NV (NL) | 1999-10-20 | — | — | EP | disclosed |
| US-5712264-A | 17-spiromethylene steroids | AKZO NOBEL N.V. (NL) | 1998-01-27 | — | — | US | disclosed |
| EP-0582338-A2 | 17-Spiromethylene steroids | Akzo Nobel N.V. (NL) | 1994-02-09 | — | — | EP | disclosed |