Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8022346 | 1.00 | PTGS2 (0.42) | PTGS2SMN1; SMN2KDM4EUSP2HSD17B10 | |
| SCHEMBL6947196 | 0.95 | KDM4E (0.45) | PTGS2SMN1; SMN2KDM4EUSP2HSD17B10 | |
| SCHEMBL6947197 | 0.95 | KDM4E (0.45) | PTGS2SMN1; SMN2KDM4EUSP2HSD17B10 | |
| SCHEMBL8427587 | 0.93 | MEN1 (0.39) | SMN1; SMN2KDM4EMAPTALDH1A1GAA | |
| SCHEMBL8427590 | 0.93 | MEN1 (0.39) | SMN1; SMN2KDM4EMAPTALDH1A1GAA | |
| SCHEMBL8424091 | 0.92 | KDM4E (0.46) | PTGS2SMN1; SMN2KDM4EUSP2HSD17B10 | |
| SCHEMBL8424094 | 0.92 | KDM4E (0.46) | PTGS2SMN1; SMN2KDM4EUSP2HSD17B10 | |
| SCHEMBL6953284 | 0.88 | ALDH1A1 (0.42) | SMN1; SMN2KDM4EMAPTALDH1A1GAA | |
| SCHEMBL6953281 | 0.88 | ALDH1A1 (0.42) | SMN1; SMN2KDM4EMAPTALDH1A1GAA | |
| SCHEMBL6952744 | 0.87 | KDM4E (0.50) | PTGS2SMN1; SMN2KDM4EUSP2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869516-A | 4-(arylaminomethylene)-2,4-dihydro-3-pyrazolones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-02-09 | — | — | US | disclosed |