Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | CACNA1B | Q00975 | 11/20 | 0.46 |
| ▸ | CACNB4 | O00305 | 6/20 | 0.46 |
| ▸ | CACNA1A | O00555 | 6/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 6/20 | 0.46 |
| ▸ | CACNG3 | O60359 | 6/20 | 0.46 |
| ▸ | CACNA1F | O60840 | 6/20 | 0.46 |
| ▸ | CACNA1H | O95180 | 6/20 | 0.46 |
| ▸ | CACNB3 | P54284 | 6/20 | 0.46 |
| ▸ | CACNA2D1 | P54289 | 6/20 | 0.46 |
| ▸ | CACNG7 | P62955 | 6/20 | 0.46 |
| ▸ | CACNA1D | Q01668 | 6/20 | 0.46 |
| ▸ | CACNB1 | Q02641 | 6/20 | 0.46 |
| ▸ | CACNG1 | Q06432 | 6/20 | 0.46 |
| ▸ | CACNB2 | Q08289 | 6/20 | 0.46 |
| ▸ | CACNA1S | Q13698 | 6/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 6/20 | 0.46 |
| ▸ | CACNA1E | Q15878 | 6/20 | 0.46 |
| ▸ | CACNA2D4 | Q7Z3S7 | 6/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8421931 | 0.96 | PTGS2 (0.63) | PTGS2PTGS1CACNA1BCACNB4CACNA1A | |
| SCHEMBL8420715 | 0.88 | PTGS2 (0.67) | PTGS2PTGS1CACNA1BCACNB4CACNA1A | |
| SCHEMBL8421778 | 0.87 | PTGS2 (0.56) | PTGS2PTGS1MEN1MAPTKMT2A | |
| SCHEMBL8421854 | 0.86 | PTGS2 (0.50) | PTGS2PTGS1CACNA1BCACNB4CACNA1A | |
| SCHEMBL8421630 | 0.86 | PTGS2 (0.50) | PTGS2PTGS1CACNA1BCACNB4CACNA1A | |
| SCHEMBL8733829 | 0.85 | PTGS2 (0.54) | PTGS2PTGS1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8420748 | 0.84 | PTGS2 (0.53) | PTGS2PTGS1CACNA1BCACNB4CACNA1A | |
| SCHEMBL8421552 | 0.84 | PTGS2 (0.53) | PTGS2PTGS1CACNA1BCACNB4CACNA1A | |
| SCHEMBL7054592 | 0.84 | PTGS2 (0.63) | PTGS2PTGS1CACNA1BCACNB4CACNA1A | |
| SCHEMBL8420838 | 0.84 | PTGS2 (0.48) | PTGS2PTGS1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908852-A | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation | G. D. SEARLE & CO. (US) | 1999-06-01 | — | — | US | disclosed |