Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MARS1 | P56192 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8421778 | 0.97 | PTGS2 (0.56) | PTGS2CYP2C9PTGS1KDM4EMEN1 | |
| SCHEMBL6903209 | 0.94 | CYP2C9 (0.61) | PTGS2CYP2C9PTGS1KDM4EMEN1 | |
| SCHEMBL8422286 | 0.93 | PTGS2 (0.52) | PTGS2CYP2C9PTGS1KDM4EMEN1 | |
| SCHEMBL8423767 | 0.93 | PTGS2 (0.52) | PTGS2CYP2C9PTGS1KDM4EMEN1 | |
| Methane SCHEMBL6309760 | 0.92 | PTGS2 (0.47) | PTGS2CYP2C9PTGS1KDM4EMEN1 | |
| SCHEMBL8422373 | 0.92 | CYP2C9 (0.55) | PTGS2CYP2C9PTGS1MMP2EGFR | |
| SCHEMBL8424076 | 0.92 | CYP2C9 (0.57) | PTGS2CYP2C9PTGS1KDM4EMEN1 | |
| SCHEMBL8420732 | 0.92 | PTGS2 (0.51) | PTGS2CYP2C9PTGS1KDM4EMEN1 | |
| SCHEMBL8423901 | 0.92 | PTGS2 (0.51) | PTGS2CYP2C9PTGS1KDM4EMEN1 | |
| SCHEMBL8423819 | 0.92 | PTGS2 (0.51) | PTGS2CYP2C9PTGS1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5510496-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |