Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 9/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.33 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27285585 | 0.78 | LMNA (0.40) | P2RX4MTNR1AMTNR1BGRIN1GRIN2A | |
| SCHEMBL2979170 | 0.76 | P2RX4 (0.42) | P2RX4MTNR1AMTNR1BPTBP1P2RX1 | |
| SCHEMBL5068751 | 0.74 | P2RX4 (0.42) | P2RX4MTNR1AMTNR1BPTBP1P2RX1 | |
| SCHEMBL7334705 | 0.73 | LMNA (0.51) | P2RX4MTNR1AMTNR1BPTBP1P2RX1 | |
| SCHEMBL11741313 | 0.72 | P2RX4 (0.43) | P2RX4MTNR1AMTNR1BPTBP1P2RX1 | |
| SCHEMBL15865153 | 0.72 | LMNA (0.40) | P2RX4MTNR1AMTNR1BGRIN1GRIN2A | |
| SCHEMBL3100027 | 0.71 | P2RX4 (0.54) | P2RX4P2RX1P2RX3SMN1; SMN2NPSR1 | |
| SCHEMBL5806375 | 0.70 | LMNA (0.37) | P2RX4MTNR1AMTNR1BRIPK1PTBP1 | |
| SCHEMBL6994927 | 0.69 | BCHE (0.43) | P2RX4P2RX1P2RX3SMN1; SMN2P2RX7 | |
| SCHEMBL5747843 | 0.68 | LMNA (0.40) | P2RX4MTNR1AMTNR1BP2RX1P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962450-A | SEDATIVE | HOFFMANN-LA ROCHE INC. (US) | 1999-10-05 | — | — | US | disclosed |
| US-5885986-A | CLEAVING, N-ALKYLATING AND REDUCING THE INTERMEDIATE FORMED BY REACTING AN OXAZOLYL AND THIAZOLYLIMIDAZOBENZO AND THIENODIAZEPINE DERIVATIVES WITH AMINE COMPOUNDS; USED AS ANXIOLYTIC AND ANTICONVULSANT OR SEDATIVE-HYPNOTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1999-03-23 | — | — | US | disclosed |