Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 12/20 | 0.42 |
| ▸ | P2RX1 | P51575 | 5/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SCN4A | P35499 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5068751 | 0.85 | P2RX4 (0.42) | P2RX4P2RX1P2RX3P2RX7SMN1; SMN2 | |
| SCHEMBL7334705 | 0.83 | LMNA (0.51) | P2RX4P2RX1P2RX3P2RX7SMN1; SMN2 | |
| SCHEMBL11741313 | 0.83 | P2RX4 (0.43) | P2RX4P2RX1P2RX3P2RX7SMN1; SMN2 | |
| SCHEMBL3100027 | 0.81 | P2RX4 (0.54) | P2RX4P2RX1P2RX3SMN1; SMN2NPSR1 | |
| SCHEMBL27285585 | 0.80 | LMNA (0.40) | P2RX4P2RX1P2RX3P2RX7LMNA | |
| SCHEMBL15865153 | 0.80 | LMNA (0.40) | P2RX4P2RX1P2RX3P2RX7SMN1; SMN2 | |
| SCHEMBL5806375 | 0.80 | LMNA (0.37) | P2RX4P2RX1P2RX3P2RX7SMN1; SMN2 | |
| SCHEMBL6994927 | 0.79 | BCHE (0.43) | P2RX4P2RX1P2RX3P2RX7SMN1; SMN2 | |
| SCHEMBL7339446 | 0.77 | LMNA (0.40) | P2RX4P2RX1P2RX3LMNATSHR | |
| SCHEMBL8423850 | 0.76 | P2RX4 (0.37) | P2RX4P2RX1P2RX3P2RX7SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781427-B2 | Process for preparing quinoline compounds and products obtained therefrom | WYETH LLC (US) | 2010-08-24 | — | — | US | disclosed |
| US-20100196714-A1 | PROCESS FOR PREPARING QUINOLINE COMPOUNDS AND PRODUCTS OBTAINED THEREFROM | WYETH (US) | 2010-08-05 | — | — | US | disclosed |
| EP-1807428-A2 | PROCESS FOR PREPARING QUINOLINE COMPOUNDS AND PRODUCTS OBTAINED THEREFROM | Wyeth (US) | 2007-07-18 | — | — | EP | disclosed |
| US-20060122385-A1 | Process for preparing quinoline compounds and products obtained therefrom | WYETH (US) | 2006-06-08 | — | — | US | disclosed |
| WO-2006052768-A2 | PROCESS FOR PREPARING QUINOLINE COMPOUNDS AND PRODUCTS OBTAINED THEREFROM | WYETH (US) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122385-A1 | Process for preparing quinoline compounds and products obtained therefrom | NNMT, QTRT1, HNMT | P2RX4 983/4885P2RX1 1507/4885P2RX3 1448/4885 |
| US-20100196714-A1 | PROCESS FOR PREPARING QUINOLINE COMPOUNDS AND PRODUCTS OBTAINED THEREFROM | NNMT, QTRT1, HNMT | P2RX4 983/4885P2RX1 1507/4885P2RX3 1448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.