Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8423873 | 0.99 | MAPT (0.47) | MAPTCYP2C9NPY5RKEAP1KMT2A | |
| SCHEMBL8423764 | 0.93 | MAPT (0.43) | MAPTNPY5RKEAP1KMT2AMEN1 | |
| SCHEMBL8422285 | 0.93 | MAPT (0.43) | MAPTNPY5RKEAP1KMT2AMEN1 | |
| SCHEMBL8422371 | 0.92 | MAPT (0.45) | MAPTCYP2C9NPY5RKMT2AMEN1 | |
| SCHEMBL8641119 | 0.87 | AURKA (0.46) | MAPTCYP2C9KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8422144 | 0.86 | MAPT (0.45) | MAPTCYP2C9NPY5RKMT2AMEN1 | |
| SCHEMBL8421857 | 0.86 | UQCRB (0.43) | MAPTCYP2C9NPY5RKMT2AMEN1 | |
| SCHEMBL8421776 | 0.86 | KDM1A (0.47) | MAPTKMT2AMEN1SMN1; SMN2RAB9A | |
| SCHEMBL8422134 | 0.86 | MAPT (0.51) | MAPTCYP2C9NPY5RKMT2AMEN1 | |
| SCHEMBL8420749 | 0.86 | MAPT (0.52) | MAPTCYP2C9NPY5RKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908852-A | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation | G. D. SEARLE & CO. (US) | 1999-06-01 | — | — | US | disclosed |