Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NAPEPLD | Q6IQ20 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9424644 | 0.83 | ALDH1A1 (0.40) | ALDH1A1GAAMAPTL3MBTL1RAB9A | |
| SCHEMBL2908207 | 0.81 | ALDH1A1 (0.40) | ALDH1A1GAAMAPTL3MBTL1SMN1; SMN2 | |
| Fumaric Acid SCHEMBL4968361 | 0.80 | POLB (0.40) | ALDH1A1GAAMAPTL3MBTL1RAB9A | |
| Fumaric Acid SCHEMBL2908209 | 0.80 | POLB (0.40) | ALDH1A1GAAMAPTL3MBTL1RAB9A | |
| Fumaric Acid SCHEMBL2908206 | 0.80 | POLB (0.40) | ALDH1A1GAAMAPTL3MBTL1RAB9A | |
| SCHEMBL9060638 | 0.79 | ALDH1A1 (0.39) | ALDH1A1GAAMAPTL3MBTL1RAB9A | |
| SCHEMBL9060642 | 0.79 | ALDH1A1 (0.39) | ALDH1A1GAAMAPTL3MBTL1RAB9A | |
| Fumaric Acid SCHEMBL17078223 | 0.76 | POLB (0.39) | ALDH1A1GAAMAPTL3MBTL1RAB9A | |
| SCHEMBL6662526 | 0.75 | LMNA (0.42) | ALDH1A1GAAMAPTL3MBTL1RAB9A | |
| Fumaric Acid SCHEMBL6139704 | 0.75 | LMNA (0.43) | ALDH1A1GAAMAPTL3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946181-A1 | USE OF 2-(2-MORPHOLINOPHENYL) GUANIDINE DERIVATIVES FOR THE TREATMENT OF DIABETES COMPLICATIONS | KNOLL AKTIENGESELLSCHAFT (DE) | 1999-10-06 | — | — | EP | claimed |
| WO-1998026782-A1 | USE OF 2-(2-MORPHOLINOPHENYL) GUANIDINE DERIVATIVES FOR THE TREATMENT OF DIABETES COMPLICATIONS | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-06-25 | — | — | WO | claimed |