Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.41 |
| ▸ | FEN1 | P39748 | 4/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 3/20 | 0.39 |
| ▸ | FABP3 | P05413 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8422279 | 0.93 | PTGS2 (0.43) | PTGS2PTGS1FABP4FABP3PDPK1 | |
| SCHEMBL8420856 | 0.92 | PTGS2 (0.42) | PTGS2ALOX5APFEN1PTGS1PTGES2 | |
| SCHEMBL8420732 | 0.88 | PTGS2 (0.51) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8422268 | 0.88 | PTGS2 (0.51) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8421770 | 0.88 | PTGS2 (0.43) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8421842 | 0.88 | PTGS2 (0.52) | PTGS2PTGS1 | |
| SCHEMBL8420716 | 0.88 | PTGS2 (0.48) | PTGS2PTGS1FABP3 | |
| SCHEMBL8424105 | 0.87 | PTGS2 (0.43) | PTGS2ALOX5APFEN1PTGS1PTGES2 | |
| SCHEMBL8420738 | 0.85 | PTGS2 (0.46) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8422379 | 0.85 | PTGS2 (0.47) | PTGS2PTGS1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908852-A | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation | G. D. SEARLE & CO. (US) | 1999-06-01 | — | — | US | disclosed |