Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 13/20 | 0.45 |
| ▸ | CACNB4 | O00305 | 8/20 | 0.45 |
| ▸ | CACNA1A | O00555 | 8/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 8/20 | 0.45 |
| ▸ | CACNG3 | O60359 | 8/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 8/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 8/20 | 0.45 |
| ▸ | CACNB3 | P54284 | 8/20 | 0.45 |
| ▸ | CACNA2D1 | P54289 | 8/20 | 0.45 |
| ▸ | CACNG7 | P62955 | 8/20 | 0.45 |
| ▸ | CACNA1D | Q01668 | 8/20 | 0.45 |
| ▸ | CACNB1 | Q02641 | 8/20 | 0.45 |
| ▸ | CACNG1 | Q06432 | 8/20 | 0.45 |
| ▸ | CACNB2 | Q08289 | 8/20 | 0.45 |
| ▸ | CACNA1S | Q13698 | 8/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 8/20 | 0.45 |
| ▸ | CACNA1E | Q15878 | 8/20 | 0.45 |
| ▸ | CACNA2D4 | Q7Z3S7 | 8/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8420748 | 0.90 | PTGS2 (0.53) | PTGS2PTGS1CACNA1BCACNB4CACNA1A | |
| SCHEMBL8424032 | 0.88 | PTGS2 (0.42) | PTGS2PTGS1FABP3 | |
| SCHEMBL8422279 | 0.86 | PTGS2 (0.43) | PTGS2PTGS1FABP3 | |
| SCHEMBL8421842 | 0.85 | PTGS2 (0.52) | PTGS2PTGS1CACNA1BCACNB4CACNA1A | |
| SCHEMBL8420732 | 0.84 | PTGS2 (0.51) | PTGS2PTGS1MARS1 | |
| SCHEMBL8422268 | 0.84 | PTGS2 (0.51) | PTGS2PTGS1MARS1 | |
| SCHEMBL8423841 | 0.84 | PTGS2 (0.68) | PTGS2PTGS1CACNA1BCACNB4CACNA1A | |
| SCHEMBL8421854 | 0.84 | PTGS2 (0.50) | PTGS2PTGS1CACNA1BCACNB4CACNA1A | |
| SCHEMBL8120566 | 0.83 | PTGS2 (0.71) | PTGS2PTGS1 | |
| SCHEMBL8420257 | 0.82 | PTGS2 (0.53) | PTGS2PTGS1CACNA1BCACNB4CACNA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908852-A | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation | G. D. SEARLE & CO. (US) | 1999-06-01 | — | — | US | disclosed |