Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 4/20 | 0.37 |
| ▸ | NOS1 | P29475 | 4/20 | 0.37 |
| ▸ | NOS2 | P35228 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29986270 | 1.00 | GAA (0.42) | GAAMAPTKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4014542 | 0.83 | GAA (0.44) | GAAMAPTKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4014545 | 0.83 | GAA (0.44) | GAAMAPTKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL14191690 | 0.83 | GAA (0.44) | GAAMAPTKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL14191688 | 0.82 | CYP3A4 (0.49) | GAAMAPTKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL1576898 | 0.81 | GAA (0.45) | GAAMAPTKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL1192238 | 0.81 | ALDH1A1 (0.44) | GAAMAPTKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL1822157 | 0.81 | LMNA (0.42) | GAAMAPTKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL1192235 | 0.81 | ALDH1A1 (0.44) | GAAMAPTKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL5491257 | 0.81 | LMNA (0.42) | GAAMAPTKMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946549-A1 | COMBINATORIAL PROCESS FOR PREPARING FUSED PYRIMIDINE LIBRARIES | ELI LILLY AND COMPANY (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998027087-A1 | COMBINATORIAL PROCESS FOR PREPARING FUSED PYRIMIDINE LIBRARIES | ELI LILLY AND COMPANY (US) | 1998-06-25 | — | — | WO | disclosed |