SCHEMBL8424641

SCHEMBL8424641

CC1CN(c2ccc(F)c(C(F)(F)F)c2)C(=NC(=O)C(F)Cl)S1

nearest known ligand 0.40

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 1/20 0.40
AR P10275 14/20 0.39
ACACB O00763 2/20 0.37
P2RX7 Q99572 1/20 0.36
TAS1R3 Q7RTX0 2/20 0.34
TAS1R1 Q7RTX1 2/20 0.34
TAS1R2 Q8TE23 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8425521 0.92 NOTUM (0.42) NOTUMARACACBP2RX7TAS1R3
SCHEMBL8424215 0.92 NOTUM (0.42) NOTUMARACACBP2RX7TAS1R3
SCHEMBL9085282 0.89 NOTUM (0.41) NOTUMARACACBP2RX7TAS1R3
SCHEMBL9255706 0.86 NOTUM (0.44) NOTUMARACACBP2RX7TAS1R3
SCHEMBL9253749 0.85 NOTUM (0.43) NOTUMARACACBP2RX7TAS1R3
SCHEMBL8428411 0.82 NOTUM (0.39) NOTUMACACB
SCHEMBL8423733 0.82 MTOR (0.33) NOTUM
SCHEMBL8428110 0.82 ALOX5 (0.39) NOTUM
SCHEMBL8424573 0.79 NOTUM (0.41) NOTUMACACBTAS1R3TAS1R1TAS1R2
SCHEMBL8423317 0.74 MTOR (0.34) NOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0636616-B1 Process for production of fluoroalkanecarboxamide derivatives SUMITOMO CHEMICAL CO (JP) 1999-10-27 EP disclosed
US-5484933-A Process for production of fluoroalkane carboxamide derivatives SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-01-16 US disclosed
EP-0636616-A1 Process for production of fluoroalkanecarboxamide derivatives SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-02-01 EP disclosed