Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 11/20 | 0.79 |
| ▸ | NR3C1 | P04150 | 10/20 | 0.53 |
| ▸ | AR | P10275 | 7/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8427053 | 0.91 | PGR (0.81) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL8427242 | 0.90 | PGR (0.81) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL8423175 | 0.88 | PGR (1.00) | PGRNR3C1ARCYP3A4 | |
| SCHEMBL8427152 | 0.85 | PGR (0.74) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL8427156 | 0.85 | PGR (0.74) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL8423485 | 0.84 | PGR (0.73) | PGRNR3C1ARCYP3A4CYP2C19 | |
| SCHEMBL8424666 | 0.83 | PGR (0.71) | PGRNR3C1ARCYP3A4 | |
| SCHEMBL9019810 | 0.83 | PGR (0.65) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL8768805 | 0.83 | PGR (0.55) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL2122881 | 0.82 | AR (0.59) | PGRNR3C1ARCYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0582338-B1 | 17-Spiromethylene steroids | AKZO NOBEL NV (NL) | 1999-10-20 | — | — | EP | disclosed |
| US-5854235-A | 17-spiromethylene steroids | AKZO NOBEL N.V. (NL) | 1998-12-29 | — | — | US | disclosed |
| US-5712264-A | 17-spiromethylene steroids | AKZO NOBEL N.V. (NL) | 1998-01-27 | — | — | US | disclosed |
| EP-0582338-A2 | 17-Spiromethylene steroids | Akzo Nobel N.V. (NL) | 1994-02-09 | — | — | EP | disclosed |