SCHEMBL8423175

C=C1CCO[C@@]12CC[C@H]1[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3[C@@H](c3ccc(N(C)C)cc3)C[C@@]12C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	PGR	P06401	18/20	1.00

▸	NR3C1	P04150	17/20	0.65

▸	AR	P10275	11/20	0.65

▸	CYP3A4	P08684	1/20	0.56

▸	CYP2C8	P10632	1/20	0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL8427242	0.90	PGR (0.81)	PGRNR3C1ARCYP3A4
SCHEMBL8427053	0.90	PGR (0.81)	PGRNR3C1ARCYP3A4
SCHEMBL8424832	0.88	PGR (0.79)	PGRNR3C1ARCYP3A4
SCHEMBL8427152	0.85	PGR (0.74)	PGRNR3C1ARCYP3A4
SCHEMBL8427156	0.85	PGR (0.74)	PGRNR3C1ARCYP3A4
SCHEMBL9019765	0.84	PGR (0.73)	PGRNR3C1ARCYP3A4CYP2C8
SCHEMBL8423485	0.84	PGR (0.73)	PGRNR3C1ARCYP3A4
SCHEMBL8424666	0.83	PGR (0.71)	PGRNR3C1ARCYP3A4
SCHEMBL9019814	0.83	PGR (0.71)	PGRNR3C1ARCYP3A4
SCHEMBL9019789	0.82	PGR (0.69)	PGRNR3C1ARCYP3A4CYP2C8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0582338-B1	17-Spiromethylene steroids	AKZO NOBEL NV (NL)	1999-10-20	—	—	EP	disclosed
EP-0582338-A2	17-Spiromethylene steroids	Akzo Nobel N.V. (NL)	1994-02-09	—	—	EP	disclosed