Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 2/20 | 0.90 |
| ▸ | MIF | P14174 | 10/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | GLA | P06280 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.62 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL126040 | 0.95 | HSD17B3 (1.00) | HSD17B3MIFKDM4EMEN1GLA | |
| SCHEMBL31015 | 0.93 | HSD17B3 (0.96) | HSD17B3MIFKDM4EMEN1GLA | |
| Phosphoric Acid SCHEMBL6259521 | 0.89 | HSD17B3 (0.87) | HSD17B3MIFKDM4EMEN1GLA | |
| SCHEMBL10852375 | 0.83 | HSD17B3 (0.71) | HSD17B3MIFKDM4EMEN1GLA | |
| SCHEMBL10791744 | 0.81 | HSD17B3 (0.74) | HSD17B3KDM4EGLAGAAALDH1A1 | |
| Bicarbonate SCHEMBL8424367 | 0.79 | MAOB (0.62) | HSD17B3KDM4EMEN1KMT2ANPC1 | |
| SCHEMBL1368289 | 0.79 | MEN1 (0.76) | HSD17B3MIFKDM4EMEN1GLA | |
| SCHEMBL37883 | 0.78 | MAOA (0.76) | HSD17B3MIFKDM4EMEN1GLA | |
| SCHEMBL11117135 | 0.78 | HSD17B3 (0.68) | HSD17B3MIFKDM4EMEN1GLA | |
| Acetic Acid SCHEMBL25422567 | 0.78 | HSD17B3 (0.59) | HSD17B3MIFKDM4EMEN1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962291-A | MONOCLONAL ANTIBODY CAPABLE OF HYDROLYZING A SUBSTRATE; HAS TWO BINDING SITES: ONE FOR FREE METAL ION, ONE FOR SUBSTRATE | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 1999-10-05 | — | — | US | disclosed |