Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | QPCT | Q16769 | 11/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | QPCTL | Q9NXS2 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7291376 | 0.83 | QPCT (0.49) | POLBPRKCIKDM4EMAPTRAD52 | |
| SCHEMBL7291370 | 0.83 | POLB (0.48) | POLBPRKCIKDM4EMAPTRAD52 | |
| SCHEMBL1976001 | 0.78 | QPCT (0.55) | PRKCIKDM4EMAPTRAD52QPCT | |
| SCHEMBL8733539 | 0.76 | QPCT (0.53) | PRKCIKDM4EMAPTRAD52QPCT | |
| SCHEMBL8425535 | 0.73 | MAPT (0.39) | POLBPRKCIKDM4EMAPTRAD52 | |
| SCHEMBL7290363 | 0.71 | QPCT (0.47) | POLBPRKCIKDM4EMAPTRAD52 | |
| SCHEMBL7290355 | 0.71 | POLB (0.43) | POLBPRKCIKDM4EMAPTRAD52 | |
| SCHEMBL11855328 | 0.70 | KDM4E (0.50) | PRKCIKDM4EMAPTRAD52QPCT | |
| SCHEMBL31190010 | 0.70 | MMP12 (0.49) | PRKCIKDM4EMAPTRAD52QPCT | |
| SCHEMBL7291365 | 0.68 | MMP12 (0.43) | POLBPRKCIKDM4EMAPTRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5942641-A | TREATMENT OF ALZHEIMER'S DISEASE, NERVOUS SYSTEM DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-24 | — | — | US | disclosed |
| EP-0655992-B1 | FLUORENONE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND CENTRAL OR PERIPHERAL NERVE DEGENERATION REPAIR AND PROTECTIVE AGENT | OTSUKA PHARMA CO LTD (JP) | 1998-11-04 | — | — | EP | disclosed |
| EP-0791570-A1 | Fluorenone derivatives, process for preparing the same and central or peripheral nerve degeneration repair and protective agent | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-27 | — | — | EP | disclosed |
| EP-0655992-A1 | FLUORENONE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND CENTRAL OR PERIPHERAL NERVE DEGENERATION REPAIR AND PROTECTIVE AGENT | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-06-07 | — | — | EP | disclosed |
| WO-1995000468-A1 | FLUORENONE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND CENTRAL OR PERIPHERAL NERVE DEGENERATION REPAIR AND PROTECTIVE AGENT | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-01-05 | — | — | WO | disclosed |