SCHEMBL8425535

SCHEMBL8425535

[CH2]CSc1ccc2[nH]cnc2c1

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.39
KDM4E B2RXH2 2/20 0.39
ALDH1A1 P00352 1/20 0.39
APEX1 P27695 1/20 0.39
RECQL P46063 1/20 0.39
BLM P54132 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
PRKCI P41743 1/20 0.37
RAD52 P43351 1/20 0.36
QPCT Q16769 7/20 0.34
QPCTL Q9NXS2 3/20 0.34
POLB P06746 1/20 0.34
MMP12 P39900 1/20 0.34
CYP3A4 P08684 1/20 0.33
NAMPT P43490 1/20 0.33
XDH P47989 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7290355 0.80 POLB (0.43) MAPTKDM4EALDH1A1APEX1RECQL
SCHEMBL1976000 0.77 QPCT (0.45) MAPTKDM4EALDH1A1APEX1RECQL
SCHEMBL8425541 0.73 POLB (0.46) MAPTKDM4EPRKCIRAD52QPCT
SCHEMBL3819646 0.73 MAPT (0.42) MAPTKDM4EALDH1A1APEX1RECQL
SCHEMBL24359637 0.72 MAPT (0.41) MAPTKDM4EALDH1A1APEX1RECQL
SCHEMBL10818466 0.72 GABRA1 (0.47) MAPTKDM4EALDH1A1APEX1RECQL
SCHEMBL13930282 0.70 MAPT (0.37) MAPTKDM4EALDH1A1APEX1RECQL
SCHEMBL1052336 0.70 MAPT (0.47) MAPTKDM4EALDH1A1APEX1RECQL
SCHEMBL24359593 0.66 TUBB4A (0.38) MAPTKDM4EALDH1A1BLMQPCT
SCHEMBL1445052 0.66 ALDH1A1 (0.56) MAPTKDM4EALDH1A1APEX1RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5942641-A TREATMENT OF ALZHEIMER'S DISEASE, NERVOUS SYSTEM DISORDERS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1999-08-24 US disclosed
EP-0655992-B1 FLUORENONE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND CENTRAL OR PERIPHERAL NERVE DEGENERATION REPAIR AND PROTECTIVE AGENT OTSUKA PHARMA CO LTD (JP) 1998-11-04 EP disclosed
EP-0791570-A1 Fluorenone derivatives, process for preparing the same and central or peripheral nerve degeneration repair and protective agent OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1997-08-27 EP disclosed
EP-0655992-A1 FLUORENONE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND CENTRAL OR PERIPHERAL NERVE DEGENERATION REPAIR AND PROTECTIVE AGENT OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1995-06-07 EP disclosed
WO-1995000468-A1 FLUORENONE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND CENTRAL OR PERIPHERAL NERVE DEGENERATION REPAIR AND PROTECTIVE AGENT OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1995-01-05 WO disclosed