SCHEMBL8425841

SCHEMBL8425841

COC(=O)/C(=C(\COC(C)=O)c1ccc(S(C)(=O)=O)cc1)c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 10/20 0.50
ESR2 Q92731 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3988166 0.89 PTGS2 (0.53) PTGS2ESR2
SCHEMBL3988162 0.89 PTGS2 (0.53) PTGS2ESR2
SCHEMBL5072268 0.89 PTGS2 (0.53) PTGS2ESR2
SCHEMBL14516363 0.84 ESR2 (0.55) PTGS2ESR2
SCHEMBL14598896 0.84 PTGS2 (0.45) PTGS2ESR2
SCHEMBL13847014 0.83 PTGS2 (0.54) PTGS2ESR2
SCHEMBL13847027 0.83 ESR2 (0.51) PTGS2ESR2
SCHEMBL14598905 0.83 PTGS2 (0.54) PTGS2ESR2
SCHEMBL14598900 0.83 PTGS2 (0.45) PTGS2ESR2
SCHEMBL14516371 0.82 ESR2 (0.43) PTGS2ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0788476-B1 STILBENE DERIVATIVES USEFUL AS CYCLOOXYGENASE-2 INHIBITORS MERCK FROSST CANADA INC (CA) 1999-10-20 EP claimed