Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.53 |
| ▸ | CTSS | P25774 | 5/20 | 0.47 |
| ▸ | CTSK | P43235 | 4/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 6/20 | 0.46 |
| ▸ | PPARG | P37231 | 5/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.45 |
| ▸ | ITGAV | P06756 | 1/20 | 0.45 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.44 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8426686 | 1.00 | ACE (0.53) | ACECTSSCTSKITGB3ITGA2B | |
| SCHEMBL8530056 | 0.90 | CTSS (0.45) | ACECTSSCTSKCTSLCTSB | |
| SCHEMBL8530060 | 0.90 | CTSS (0.45) | ACECTSSCTSKCTSLCTSB | |
| SCHEMBL8426689 | 0.86 | ALDH1A1 (0.48) | ACECTSSCTSKSCN9ACTSL | |
| SCHEMBL8426691 | 0.86 | ALDH1A1 (0.48) | ACECTSSCTSKSCN9ACTSL | |
| SCHEMBL25177899 | 0.85 | ACE (0.50) | ACECTSSCTSKITGB3ITGA2B | |
| SCHEMBL539422 | 0.85 | ACE (0.50) | ACECTSSCTSKITGB3ITGA2B | |
| SCHEMBL3376657 | 0.85 | ACE (0.50) | ACECTSSCTSKITGB3ITGA2B | |
| SCHEMBL8526061 | 0.81 | ACE (0.45) | ACECTSSCTSKITGB3ITGA2B | |
| SCHEMBL8526064 | 0.81 | ACE (0.45) | ACECTSSCTSKITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874472-A | Aminoacid derivatives as no synthase inhibitors | GLAXO WELLCOME INC. (US) | 1999-02-23 | — | — | US | disclosed |
| EP-0705257-B1 | AMINOACID DERIVATIVES AS NO SYNTHASE INHIBITORS | WELLCOME FOUND (GB) | 1998-03-11 | — | — | EP | disclosed |