SCHEMBL8427290

SCHEMBL8427290

CSCC(=O)c1cc(Cl)cc(Cl)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TPMT P51580 1/20 0.46
RAB9A P51151 1/20 0.42
HDAC3 O15379 4/20 0.39
HDAC1 Q13547 4/20 0.39
HDAC2 Q92769 4/20 0.39
HDAC6 Q9UBN7 4/20 0.39
HDAC4 P56524 3/20 0.39
HDAC7 Q8WUI4 3/20 0.39
HDAC10 Q969S8 3/20 0.39
HDAC11 Q96DB2 3/20 0.39
HDAC8 Q9BY41 3/20 0.39
HDAC9 Q9UKV0 3/20 0.39
HDAC5 Q9UQL6 3/20 0.39
GRN P28799 4/20 0.37
SORT1 Q99523 4/20 0.37
HCAR1 Q9BXC0 1/20 0.36
FABP4 P15090 2/20 0.36
RXRA P19793 1/20 0.34
RXRB P28702 1/20 0.34
MEN1 O00255 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10419313 0.81 ERCC5 (0.56) MEN1KMT2AALDH1A1LMNA
SCHEMBL2220646 0.79 HDAC3 (0.57) RAB9AHDAC3HDAC1HDAC2HDAC6
SCHEMBL633305 0.76 TPMT (0.52) TPMTRAB9AGRNSORT1HCAR1
SCHEMBL6745410 0.75 HDAC3 (0.67) HDAC3HDAC1HDAC2HDAC6HDAC4
SCHEMBL5276295 0.73 GSK3B (0.60) TPMTRAB9AHCAR1FABP4RXRA
SCHEMBL1448228 0.73 TPMT (0.54) TPMTRAB9AGRNSORT1HCAR1
SCHEMBL12788976 0.72 TPMT (0.48) TPMTRAB9AGRNSORT1HCAR1
SCHEMBL1198757 0.71 GSK3B (0.61) TPMTRAB9AHCAR1FABP4RXRA
SCHEMBL10387740 0.71 TPMT (0.52) TPMTRAB9AGRNSORT1HCAR1
SCHEMBL15189680 0.71 TPMT (0.52) TPMTRAB9AGRNSORT1HCAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5945382-A AND A METHOD OF THEIR PREPARATION BY CHLORINATION OF AN INTERMEDIATE ARYLPYRAZOLE; PROTECTION AGAINST FUNGAL DISEASES IN TOMATO, RICE, AND WHEAT PLANTS RHONE-POULENC AGROCHIMIE (FR) 1999-08-31 US disclosed
EP-0638070-A1 FUNGICIDAL ARYLPYRAZOLES RHONE-POULENC AGROCHIMIE (FR) 1995-02-15 EP disclosed
WO-1993022287-A1 FUNGICIDAL ARYLPYRAZOLES RHONE POULENC AGROCHIMIE (FR) 1993-11-11 WO disclosed