Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | SCN1A | P35498 | 1/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8841108 | 0.95 | KDM4E (0.61) | GPR119KDM4EPKMTDP1MEN1 | |
| SCHEMBL18891231 | 0.91 | KDM4E (0.64) | GPR119KDM4EPKMMEN1KMT2A | |
| SCHEMBL4209884 | 0.85 | KDM4E (0.65) | GPR119KDM4EPKMLIMK2MEN1 | |
| SCHEMBL22983598 | 0.85 | ACKR3 (0.51) | GPR119KDM4EPKMSCN1ASCN2A | |
| SCHEMBL28771668 | 0.85 | ACKR3 (0.51) | GPR119KDM4EPKMSCN1ASCN2A | |
| SCHEMBL23006166 | 0.85 | ACKR3 (0.51) | GPR119KDM4EPKMSCN1ASCN2A | |
| SCHEMBL389035 | 0.84 | GPR119 (0.55) | GPR119KDM4EPKMFAAH | |
| SCHEMBL22633427 | 0.84 | KDM4E (0.61) | GPR119KDM4EPKMLIMK2MEN1 | |
| SCHEMBL21047201 | 0.81 | KDM4E (0.61) | GPR119KDM4EPKMMEN1KMT2A | |
| SCHEMBL19859549 | 0.81 | KDM4E (0.61) | GPR119KDM4EPKMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5973156-A | Piperidine and tetrahydropyridine derivatives | MERCK SHARP & DOME LTD. (GB) | 1999-10-26 | — | — | US | disclosed |