Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14721005 | 0.91 | HPGD (0.56) | PTPN1POLBGAAKDM4EHSD17B10 | |
| SCHEMBL2134115 | 0.84 | PTPN1 (0.53) | PTPN1 | |
| SCHEMBL27642525 | 0.84 | SMN1; SMN2 (0.59) | MEN1KMT2APOLBGAAKDM4E | |
| SCHEMBL7038455 | 0.84 | GAA (0.56) | PTPN1MEN1KMT2AGAAKDM4E | |
| SCHEMBL23605917 | 0.83 | GAA (0.52) | PTPN1MEN1KMT2APOLBGAA | |
| SCHEMBL3929739 | 0.82 | PTPN1 (0.57) | PTPN1MEN1KMT2AGAAKDM4E | |
| SCHEMBL8603637 | 0.81 | HPGD (0.50) | PTPN1MEN1KMT2APOLBGAA | |
| SCHEMBL6809898 | 0.81 | ALDH1A1 (0.51) | PTPN1MEN1KMT2APOLBGAA | |
| SCHEMBL5531605 | 0.81 | GAA (0.53) | PTPN1MEN1KMT2APOLBGAA | |
| SCHEMBL16569366 | 0.81 | KDM4E (0.53) | PTPN1GAAKDM4EHSD17B10NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922733-A | ADMINISTERING TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS SUCH AS ANXIETY, DEPRESSION, EPILEPSY, OBSESSIVE COMPULSIVE DISORDERS, ANOREXIA, BULIMIA AND ALZHEIMER'S DISEASE | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-07-13 | — | — | US | disclosed |
| EP-0770076-A1 | BENZOCONDENSED FIVE MEMBERED HETEROCYCLE CARBOXAMIDES AS 5HT2B/2C RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-05-02 | — | — | EP | disclosed |
| WO-1996002537-A1 | BENZOCONDENSED FIVE MEMBERED HETEROCYCLE CARBOXAMIDES AS 5HT2B/2C RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-02-01 | — | — | WO | disclosed |