Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8428093 | 0.89 | GAA (0.47) | GAAKMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL8427522 | 0.88 | GAA (0.46) | GAAKMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL8424073 | 0.87 | GAA (0.43) | GAAKMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL8423717 | 0.87 | GAA (0.43) | GAAKMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL8425391 | 0.86 | GAA (0.43) | GAAKMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL5976498 | 0.83 | SHMT2 (0.59) | GAAKMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL8425294 | 0.83 | GAA (0.45) | GAAKMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL8428102 | 0.80 | ALDH1A1 (0.42) | GAAKMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL8425478 | 0.80 | CD274 (0.48) | GAAALDH1A1L3MBTL1MAPTKDM4E | |
| SCHEMBL8423942 | 0.79 | ALDH1A1 (0.43) | GAAKMT2AMEN1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869516-A | 4-(arylaminomethylene)-2,4-dihydro-3-pyrazolones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-02-09 | — | — | US | disclosed |