Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 10/20 | 0.85 |
| ▸ | MME | P08473 | 4/20 | 0.85 |
| ▸ | APP | P05067 | 1/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Omapatrilat SCHEMBL4818275 | 0.92 | ACE (1.00) | ACEMMEAPP | |
| SCHEMBL6891502 | 0.92 | ACE (0.89) | ACEMMEAPP | |
| Omapatrilat SCHEMBL1047530 | 0.92 | ACE (1.00) | ACEMMEAPP | |
| Omapatrilat SCHEMBL130098 | 0.92 | ACE (1.00) | ACEMMEAPP | |
| Omapatrilat SCHEMBL49355 | 0.92 | ACE (1.00) | ACEMMEAPP | |
| Omapatrilat SCHEMBL23468397 | 0.92 | ACE (1.00) | ACEMMEAPP | |
| Omapatrilat SCHEMBL4330098 | 0.92 | ACE (1.00) | ACEMMEAPP | |
| Omapatrilat SCHEMBL20130837 | 0.92 | ACE (1.00) | ACEMMEAPP | |
| Omapatrilat SCHEMBL30924348 | 0.92 | ACE (1.00) | ACEMMEAPP | |
| Omapatrilat SCHEMBL30924347 | 0.92 | ACE (1.00) | ACEMMEAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859239-A | Mercaptoalkanoylamino and acylmercaptoalkanoylamino benzoxazepines and benzothiazepines | E. R. SQUIBB & SONS, INC. (US) | 1999-01-12 | — | — | US | disclosed |
| US-5856477-A | HYPOTENSIVE AGENTS; CONGESTIVE HEART FAILURE | E. R. SQUIBB & SONS, INC. (US) | 1999-01-05 | — | — | US | disclosed |