Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 5/20 | 0.47 |
| ▸ | IKBKB | O14920 | 4/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | RARG | P13631 | 5/20 | 0.32 |
| ▸ | RARB | P10826 | 3/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.30 |
| ▸ | GOT1 | P17174 | 1/20 | 0.30 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8690715 | 0.86 | IKBKB (0.46) | RARAIKBKBRARGRARB | |
| SCHEMBL8428669 | 0.84 | RARA (0.52) | RARAIKBKBS1PR1RARGRARB | |
| SCHEMBL8428794 | 0.83 | IKBKB (0.32) | RARAIKBKBS1PR1RARGRARB | |
| SCHEMBL8571683 | 0.81 | IKBKB (0.48) | RARAIKBKBS1PR1RARGRARB | |
| SCHEMBL8424327 | 0.81 | IKBKB (0.59) | RARAIKBKBRARGRARBMEN1 | |
| SCHEMBL8690854 | 0.80 | IKBKB (0.50) | RARAIKBKBRARGRARBMEN1 | |
| SCHEMBL8690960 | 0.80 | IKBKB (0.50) | RARAIKBKBS1PR1RARGRARB | |
| SCHEMBL8568935 | 0.80 | IKBKB (0.46) | RARAIKBKBS1PR1RARGRARB | |
| SCHEMBL8691125 | 0.79 | IKBKB (0.49) | RARAIKBKBRARGRARB | |
| SCHEMBL8572145 | 0.77 | RARA (0.55) | RARAIKBKBS1PR1RARGRARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0776885-B1 | Diaromatic compounds with an adamantyl group in the ortho position, pharmaceutical and cosmetic compositions containing them and uses | CIRD GALDERMA (FR) | 1999-10-27 | — | — | EP | disclosed |
| US-5786379-A | Adamantyl-substituted biaromatic compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-07-28 | — | — | US | disclosed |
| EP-0776885-A1 | Diaromatic compounds with an adamantyl group in the ortho position, pharmaceutical and cosmetic compositions containing them and uses | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1997-06-04 | — | — | EP | disclosed |