Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 4/20 | 0.46 |
| ▸ | ACHE | P22303 | 4/20 | 0.46 |
| ▸ | BACE1 | P56817 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8426939 | 1.00 | KDM4E (0.58) | KDM4ESMN1; SMN2HIF1AEPAS1LMNA | |
| SCHEMBL8429503 | 0.88 | KDM4E (0.64) | KDM4ESMN1; SMN2ALDH1A1DRD2HTR2A | |
| SCHEMBL8429501 | 0.88 | KDM4E (0.64) | KDM4ESMN1; SMN2ALDH1A1DRD2HTR2A | |
| SCHEMBL8429465 | 0.87 | KDM4E (0.60) | KDM4ESMN1; SMN2LMNAMAPTMAPK1 | |
| SCHEMBL8429460 | 0.87 | KDM4E (0.60) | KDM4ESMN1; SMN2LMNAMAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL8428835 | 0.87 | KDM4E (0.66) | KDM4ESMN1; SMN2DRD2HTR2ADRD4 | |
| Hydrochloric Acid SCHEMBL8428831 | 0.87 | KDM4E (0.66) | KDM4ESMN1; SMN2DRD2HTR2ADRD4 | |
| SCHEMBL8429502 | 0.86 | KDM4E (0.62) | KDM4ESMN1; SMN2DRD2SIGMAR1DRD4 | |
| SCHEMBL8429499 | 0.86 | KDM4E (0.62) | KDM4ESMN1; SMN2DRD2SIGMAR1DRD4 | |
| SCHEMBL8426889 | 0.85 | KDM4E (0.60) | KDM4ESMN1; SMN2DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861407-A | Tetrahydropyridine derivatives as dopamine receptor subtype ligands | MERCK SHARP & DOHME, LTD. (GB) | 1999-01-19 | — | — | US | disclosed |