Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | GPR183 | P32249 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 4/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8429502 | 1.00 | KDM4E (0.62) | KDM4ESMN1; SMN2SIGMAR1GPR183DRD4 | |
| SCHEMBL8427010 | 0.95 | KDM4E (0.62) | KDM4ESMN1; SMN2SIGMAR1DRD4DRD2 | |
| SCHEMBL8427008 | 0.95 | KDM4E (0.62) | KDM4ESMN1; SMN2SIGMAR1DRD4DRD2 | |
| SCHEMBL8426855 | 0.93 | KDM4E (0.70) | KDM4ESMN1; SMN2DRD4DRD2DRD3 | |
| SCHEMBL8426856 | 0.93 | KDM4E (0.70) | KDM4ESMN1; SMN2DRD4DRD2DRD3 | |
| SCHEMBL8429501 | 0.92 | KDM4E (0.64) | KDM4ESMN1; SMN2SIGMAR1DRD4DRD2 | |
| SCHEMBL8429503 | 0.92 | KDM4E (0.64) | KDM4ESMN1; SMN2SIGMAR1DRD4DRD2 | |
| Hydrochloric Acid SCHEMBL8428831 | 0.90 | KDM4E (0.66) | KDM4ESMN1; SMN2DRD4DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL8428835 | 0.90 | KDM4E (0.66) | KDM4ESMN1; SMN2DRD4DRD2DRD3 | |
| SCHEMBL8426807 | 0.88 | KDM4E (0.55) | KDM4ESMN1; SMN2DRD4DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861407-A | Tetrahydropyridine derivatives as dopamine receptor subtype ligands | MERCK SHARP & DOHME, LTD. (GB) | 1999-01-19 | — | — | US | disclosed |