Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8431037 | 0.91 | DHODH (0.37) | ALDH1A1HPGDRAB9AMAPTKMT2A | |
| SCHEMBL8429040 | 0.89 | P2RX1 (0.34) | ALDH1A1CTSL | |
| SCHEMBL8430960 | 0.89 | MAPT (0.35) | ALDH1A1HPGDRAB9AMAPTKMT2A | |
| SCHEMBL8431235 | 0.89 | RXFP1 (0.32) | RAB9AMAPTKMT2A | |
| SCHEMBL8428895 | 0.87 | TRPV4 (0.35) | MAPTKMT2A | |
| SCHEMBL8429055 | 0.87 | TRPV4 (0.35) | MAPTKMT2A | |
| SCHEMBL8432441 | 0.85 | KMT2A (0.32) | RAB9AKMT2A | |
| SCHEMBL8432891 | 0.84 | DHODH (0.36) | ALDH1A1HPGDRAB9AMAPTKMT2A | |
| SCHEMBL8431435 | 0.84 | CA1 (0.32) | ALDH1A1RAB9AMAPTKMT2A | |
| SCHEMBL8431423 | 0.83 | DHODH (0.34) | NR1H4ALDH1A1RAB9AMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | claimed |
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |