Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.31 |
| ▸ | PPARD | Q03181 | 2/20 | 0.31 |
| ▸ | PPARA | Q07869 | 2/20 | 0.31 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 2/20 | 0.31 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8428895 | 1.00 | TRPV4 (0.35) | TRPV4RXFP1PPARGPPARDPPARA | |
| SCHEMBL8431235 | 0.93 | RXFP1 (0.32) | RXFP1KCNK9KMT2AMAPTCYP1A2 | |
| SCHEMBL8432619 | 0.91 | TRPV4 (0.35) | TRPV4RXFP1MAPTCA1CA2 | |
| SCHEMBL8430960 | 0.89 | MAPT (0.35) | RXFP1KMT2AMAPTCYP1A2CYP3A4 | |
| SCHEMBL8431037 | 0.89 | DHODH (0.37) | TRPV4KMT2AMAPTCA1CA2 | |
| SCHEMBL8432441 | 0.89 | KMT2A (0.32) | RXFP1KMT2ACYP1A2CA1CA2 | |
| SCHEMBL8429189 | 0.88 | RXFP1 (0.37) | TRPV4RXFP1KCNK9KMT2AMAPT | |
| SCHEMBL8431435 | 0.88 | CA1 (0.32) | RXFP1KMT2AMAPTCA1CA2 | |
| SCHEMBL8429159 | 0.87 | NR1H4 (0.32) | KMT2AMAPT | |
| SCHEMBL8430969 | 0.86 | NR1H4 (0.33) | PPARGPPARDPPARAKCNK9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | claimed |
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |