SCHEMBL8429241

SCHEMBL8429241

CCC(=CN(C)C(=O)OC(C)(C)C)c1ccc(C(N)=O)cn1

nearest known ligand 0.39

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
AAK1 Q2M2I8 1/20 0.38
NNMT P40261 4/20 0.37
SMN1; SMN2 Q16637 1/20 0.35
KDM4E B2RXH2 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
PARP10 Q53GL7 1/20 0.33
EPHX2 P34913 1/20 0.33
MAPK1 P28482 2/20 0.33
OPRM1 P35372 2/20 0.31
OPRD1 P41143 2/20 0.31
OPRK1 P41145 2/20 0.31
TGFBR1 P36897 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8429670 0.80 TRPV1 (0.36) AAK1SMN1; SMN2L3MBTL1
SCHEMBL8431440 0.72 NNMT (0.50) NNMTSMN1; SMN2KDM4EL3MBTL1PARP10
SCHEMBL6663166 0.68 AAK1 (0.46) AAK1NNMTSMN1; SMN2KDM4EL3MBTL1
SCHEMBL22182995 0.66 NNMT (0.52) NNMTSMN1; SMN2KDM4EL3MBTL1MAPK1
SCHEMBL25347292 0.64 PARP10 (0.43) AAK1L3MBTL1PARP10EPHX2
SCHEMBL978974 0.64 NNMT (0.63) NNMTSMN1; SMN2KDM4EL3MBTL1MAPK1
SCHEMBL7081537 0.63 NNMT (0.57) NNMTSMN1; SMN2KDM4EL3MBTL1MAPK1
SCHEMBL840090 0.63 NNMT (0.45) NNMTSMN1; SMN2KDM4EL3MBTL1PARP10
SCHEMBL14829450 0.63 AOC3 (0.45) AAK1SMN1; SMN2PARP10EPHX2
Hydrochloric Acid SCHEMBL6485765 0.63 NNMT (0.61) NNMTSMN1; SMN2KDM4EL3MBTL1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5861423-A SIDE EFFECT REDUCTION; ADMINISTERING TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS; ALZHEIMER*S AND PARKINSON*S DISEASE; ATTENTION DEFICIT DISORDER, SCHIZOPHRENIA TARGACEPT, INC., A CORPORATION OF DELAWARE 1999-01-19 US disclosed
US-5811442-A ADMINISTERING ARYL SUBSTITUTED OLEFINIC AMINE COMPOUND IN AN AMOUNT SUFFICIENT TO SELECTIVELY BIND TO AND AFFECT NICOTINIC CHOLINERGIC RECEPTOR SUBTYPES CONTAINING BETA2 SUBUNITS TARGACEPT, INC. 1998-09-22 US disclosed