Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NNMT | P40261 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.31 |
| ▸ | FPR3 | P25089 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6664110 | 0.80 | FPR3 (0.37) | AAK1KDM4EPDK2FPR3FPR2 | |
| SCHEMBL6658560 | 0.80 | AAK1 (0.33) | AAK1GBA1PDK2METAP2 | |
| SCHEMBL6663163 | 0.79 | RAF1 (0.46) | AAK1GBA1PDK2 | |
| SCHEMBL7099269 | 0.72 | TBXAS1 (0.49) | KDM4EL3MBTL1NPC1RAB9A | |
| SCHEMBL7099273 | 0.72 | TBXAS1 (0.49) | KDM4EL3MBTL1NPC1RAB9A | |
| SCHEMBL3697124 | 0.72 | OPRM1 (0.55) | AAK1NNMTOPRM1OPRD1OPRK1 | |
| SCHEMBL6660066 | 0.71 | KDM4E (0.50) | KDM4EL3MBTL1NNMTSMN1; SMN2 | |
| SCHEMBL31371000 | 0.68 | PDK2 (0.47) | AAK1KDM4EGBA1PDK2 | |
| SCHEMBL14829450 | 0.68 | AOC3 (0.45) | AAK1SMN1; SMN2PARP10 | |
| SCHEMBL8429241 | 0.68 | AAK1 (0.38) | AAK1KDM4EL3MBTL1NNMTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973743-B1 | PHARMACEUTICAL COMPOSITIONS INCORPORATING ARYL SUBSTITUTED OLEFINIC AMINE COMPOUNDS | TARGACEPT INC (US) | 2004-08-25 | — | — | EP | disclosed |
| US-6531606-B1 | Nicotinic compound: N-methyl-4-(3-(5-phenylpyridin)yl)-3-buten-1-amine; capable of affecting nicotinic chlorinergic receptors | TARGACEPT, INC. | 2003-03-11 | — | — | US | disclosed |
| US-6274606-B1 | ADMINISTERING COMPOUNDS SUCH AS (E)-N-METHYL-4-(3-(5-ISO PROPOXYPYRIDIN)YL)-3-BUTEN-1-AMINE TO TREAT PARKINSON'S DISEASE, TOURETTE'S SYNDROME, ATTENTION DEFICIT DISORDER, SCHIZOPHRENIA, AND ALZHEIMER'S DISEASE | TARGACEPT, INC. | 2001-08-14 | — | — | US | disclosed |