Phenacyl Chloride

Phenacyl Chloride

SCHEMBL8429323

CC(C)[C@H](N)C(=O)O.O=C(CCl)c1ccccc1

nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.63
GSK3B P49841 3/20 0.63
MAPK1 P28482 2/20 0.63
HIF1A Q16665 2/20 0.63
TRPA1 O75762 1/20 0.63
SLC7A5 Q01650 1/20 0.50
TSHR P16473 1/20 0.44
SMN1; SMN2 Q16637 4/20 0.44
LMNA P02545 3/20 0.44
MAPT P10636 3/20 0.44
HPGD P15428 2/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
SLC1A2 P43004 2/20 0.42
TP53 P04637 2/20 0.42
KMT2A Q03164 3/20 0.42
MEN1 O00255 2/20 0.42
KDM4E B2RXH2 1/20 0.42
CYP3A4 P08684 1/20 0.42
ALOX15 P16050 1/20 0.42
CES1 P23141 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenacyl Chloride SCHEMBL4459422 0.88 ALDH1A1 (0.70) ALDH1A1GSK3BMAPK1HIF1ATRPA1
Valine SCHEMBL9830598 0.85 SLC7A5 (0.52) ALDH1A1GSK3BMAPK1HIF1ATRPA1
Benzoyl Chloride SCHEMBL8782027 0.81 SLC7A5 (0.56) ALDH1A1MAPK1SLC7A5TSHRSMN1; SMN2
Benzoic Acid SCHEMBL5792949 0.80 SLC7A5 (0.60) ALDH1A1SLC7A5TSHRSMN1; SMN2LMNA
Benzophenone SCHEMBL11351378 0.80 SLC7A5 (0.60) ALDH1A1MAPK1HIF1ASLC7A5SMN1; SMN2
Phenacyl Chloride SCHEMBL2314766 0.80 ALDH1A1 (1.00) ALDH1A1GSK3BMAPK1HIF1ATRPA1
Phenacyl Chloride SCHEMBL55444 0.80 ALDH1A1 (1.00) ALDH1A1GSK3BMAPK1HIF1ATRPA1
Acetophenone SCHEMBL10591742 0.79 SLC7A5 (0.58) ALDH1A1SLC7A5SMN1; SMN2LMNAMAPT
Valine SCHEMBL6473828 0.79 SLC7A5 (0.58) ALDH1A1MAPK1SLC7A5TSHRSMN1; SMN2
Phenacyl Chloride SCHEMBL27980271 0.78 GSK3B (0.79) ALDH1A1GSK3BMAPK1HIF1ATRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5945382-A AND A METHOD OF THEIR PREPARATION BY CHLORINATION OF AN INTERMEDIATE ARYLPYRAZOLE; PROTECTION AGAINST FUNGAL DISEASES IN TOMATO, RICE, AND WHEAT PLANTS RHONE-POULENC AGROCHIMIE (FR) 1999-08-31 US disclosed
EP-0638070-A1 FUNGICIDAL ARYLPYRAZOLES RHONE-POULENC AGROCHIMIE (FR) 1995-02-15 EP disclosed
WO-1993022287-A1 FUNGICIDAL ARYLPYRAZOLES RHONE POULENC AGROCHIMIE (FR) 1993-11-11 WO disclosed
WO-1989009771-A1 NOVEL 1-ARYL-1-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIHYDROISOBENZOFURANS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SCHERING CORPORATION (US) 1989-10-19 WO disclosed
EP-0337019-A1 Novel 1-aryl-1-(1H-imidazol-1'-yl methyl)-1,3-dihydroisobenzofurans, their preparation and pharmaceutical compositions containing them. SCHERING CORPORATION (US) 1989-10-18 EP disclosed