Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | AGXT | P21549 | 4/20 | 0.32 |
| ▸ | IDO1 | P14902 | 3/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | TTR | P02766 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
| ▸ | ERN1 | O75460 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2411686 | 0.89 | AGXT (0.38) | PTGS2AGXTIDO1CA1CA2 | |
| SCHEMBL2409494 | 0.85 | TSHR (0.39) | AGXTIDO1CA1CA2TTR | |
| SCHEMBL795694 | 0.83 | ERN1 (0.41) | PTGS2AGXTIDO1CA1CA2 | |
| SCHEMBL14115011 | 0.82 | TSHR (0.40) | PTGS2AGXTIDO1CA1CA2 | |
| SCHEMBL21316226 | 0.79 | KDM4E (0.39) | CA1CA2KDM4ETHRBTDP1 | |
| SCHEMBL10735808 | 0.79 | TTR (0.42) | AGXTIDO1TTR | |
| Ether SCHEMBL28044990 | 0.78 | TDP1 (0.49) | AGXTIDO1TTRKDM4ETHRB | |
| SCHEMBL134443 | 0.76 | IDO1 (0.46) | PTGS2AGXTIDO1ACACBERN1 | |
| SCHEMBL10735462 | 0.76 | LTA4H (0.41) | AGXTIDO1CA1CA2TTR | |
| SCHEMBL2408827 | 0.76 | TRPV1 (0.34) | CA1CA2KDM4ETHRBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877321-A | NEUROKININ RECEPTOR | SANOFI (FR) | 1999-03-02 | — | — | US | disclosed |
| US-5446052-A | Used for treatment of substance p-and neurokinin-dependent pathology such as analgesia and inflmmation | SANOFI (FR) | 1995-08-29 | — | — | US | disclosed |
| US-5300648-A | Analgesics, antiinflammatory agents | SOCIETE ANONYME: ELF SANOFI (FR) | 1994-04-05 | — | — | US | disclosed |