Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 15/20 | 0.65 |
| ▸ | CACNB1 | Q02641 | 15/20 | 0.65 |
| ▸ | CACNA1B | Q00975 | 13/20 | 0.65 |
| ▸ | CACNA1C | Q13936 | 11/20 | 0.65 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.65 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.60 |
| ▸ | CACNA1A | O00555 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5267438 | 0.96 | CACNA2D1 (0.70) | CACNA2D1CACNB1CACNA1BCACNA1CCACNA1H | |
| SCHEMBL8446337 | 0.88 | CACNA2D1 (0.77) | CACNA2D1CACNB1CACNA1BCACNA1CCACNA1H | |
| SCHEMBL5266285 | 0.87 | CACNA2D1 (0.86) | CACNA2D1CACNB1CACNA1BCACNA1CCACNA1H | |
| SCHEMBL5549190 | 0.81 | CACNA2D1 (0.73) | CACNA2D1CACNB1CACNA1BCACNA1CCACNA1H | |
| Z160 SCHEMBL4180792 | 0.80 | CACNA2D1 (1.00) | CACNA2D1CACNB1CACNA1BCACNA1CCACNA1H | |
| SCHEMBL15266877 | 0.78 | SMAD3 (0.60) | — | |
| SCHEMBL3395399 | 0.78 | CACNA2D1 (0.71) | CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL5270085 | 0.77 | CACNA2D1 (0.77) | CACNA2D1CACNB1CACNA1BCACNA1CCACNA1H | |
| SCHEMBL5266301 | 0.76 | CACNA2D1 (1.00) | CACNA2D1CACNB1CACNA1BCACNA1CCACNA1H | |
| SCHEMBL5268519 | 0.76 | CACNA2D1 (1.00) | CACNA2D1CACNB1CACNA1BCACNA1CCACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040259866-A1 | Calcium channel blockers comprising two benzhydril moieties | ZALICUS PHARMACEUTICALS LTD. (CA) | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259866-A1 | Calcium channel blockers comprising two benzhydril moieties | CACNA1C, CACNA1F, CACNA1D | CACNA2D1 41/4885CACNB1 14/4885CACNA1B 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.