SCHEMBL8429653

SCHEMBL8429653

CCOCn1c([Se]c2cc(F)cc(F)c2)c(CC)c(=O)[nH]c1=O

nearest known ligand 0.35

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.35
ALDH1A1 P00352 1/20 0.32
DAO P14920 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8430823 0.88 MPO (0.32)
SCHEMBL7534089 0.87 SMN1; SMN2 (0.35) SMN1; SMN2ALDH1A1
SCHEMBL8426904 0.84 ALDH1A1 (0.31) ALDH1A1
SCHEMBL1443402 0.83 ALDH1A1 (0.43) SMN1; SMN2ALDH1A1
SCHEMBL8426962 0.81 ALDH1A1 (0.37) SMN1; SMN2ALDH1A1DAO
SCHEMBL9016402 0.76 UPP1 (0.38) ALDH1A1
SCHEMBL7541334 0.75 GAA (0.33)
SCHEMBL7535269 0.74 ALDH1A1 (0.54) SMN1; SMN2ALDH1A1
SCHEMBL9016369 0.74 ALDH1A1 (0.56) SMN1; SMN2ALDH1A1
SCHEMBL8429024 0.73 MPO (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5889013-A REACTING AN URACIL COMPOUND WITH N, O-BIS/TRIMETHYLSILYL/ACETAMIDE FOLLOWED BY TETRABUTYLAMMONIUM IODIDE AND CHLOROMETHYL ETHER COMPOUND AND THEN REACTING WITH ARYL SELENOL IN A BASE SUNKYONG INDUSTRIES CO., INC. (KR) 1999-03-30 US disclosed
EP-0748316-A1 PYRIMIDINE ACYCLONUCLEOSIDE DERIVATIVES SUNKYONG INDUSTRIES CO., LTD. (KR) 1996-12-18 EP disclosed
WO-1995023138-A1 PYRIMIDINE ACYCLONUCLEOSIDE DERIVATIVES SUNKYONG INDUSTRIES CO., LTD. (KR) 1995-08-31 WO disclosed