SCHEMBL8429905

SCHEMBL8429905

COc1cc(CCc2ccccc2O)ccc1F

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 2/20 0.50
TSHR P16473 2/20 0.50
MAPK1 P28482 1/20 0.50
ABCB1 P08183 1/20 0.49
LMNA P02545 1/20 0.49
GLA P06280 1/20 0.49
AKR1B1 P15121 1/20 0.48
PTPN1 P18031 1/20 0.48
TUBB4A P04350 1/20 0.47
TUBB P07437 1/20 0.47
TUBA3C P0DPH7 1/20 0.47
TUBA1B P68363 1/20 0.47
TUBA4A P68366 1/20 0.47
TUBB4B P68371 1/20 0.47
TUBB3 Q13509 1/20 0.47
TUBB2A Q13885 1/20 0.47
TUBB8 Q3ZCM7 1/20 0.47
TUBA3E Q6PEY2 1/20 0.47
TUBA1A Q71U36 1/20 0.47
TUBA1C Q9BQE3 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8706804 0.86 ABCB1 (0.64) ABCB1AKR1B1PTPN1TUBB4ATUBB
SCHEMBL8432995 0.85 TAAR1 (0.54) TAAR1TSHRMAPK1LMNAGLA
SCHEMBL30873082 0.83 TUBB4A (0.62) TSHRABCB1LMNAAKR1B1PTPN1
SCHEMBL27182924 0.83 TUBB4A (0.62) TSHRABCB1LMNAAKR1B1PTPN1
SCHEMBL14533759 0.81 SMN1; SMN2 (0.51) ABCB1
SCHEMBL8703845 0.80 ABCB1 (0.64) ABCB1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL13107402 0.78 ABCB1 (0.54) ABCB1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL1239104 0.76 TAAR1 (0.51) TAAR1TSHRMAPK1LMNAGLA
SCHEMBL8704419 0.76 MPO (0.68) TAAR1TSHRMAPK1ABCB1LMNA
SCHEMBL31527816 0.75 TUBB4A (0.59) TSHRABCB1LMNAAKR1B1PTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0958817-A1 COMPOSITION CONTAINING DIARYLALKANE DERIVATIVE AS THE ACTIVE INGREDIENT FOR TREATING OR PREVENTING PANCREATITIS SANKYO COMPANY LIMITED (JP) 1999-11-24 EP disclosed