Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 2/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 11/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430247 | 0.91 | RXRA (0.33) | RXRAPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8430226 | 0.87 | PPARG (0.39) | RXRAPPARGPTGS1 | |
| SCHEMBL8432051 | 0.84 | PPARG (0.41) | RXRAPPARGMEN1CYP1A2CYP3A4 | |
| SCHEMBL8430304 | 0.83 | MAPT (0.36) | MAOAMAOBMEN1MAPTKMT2A | |
| SCHEMBL8430717 | 0.67 | RXRA (0.39) | RXRAPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8430782 | 0.66 | RXRA (0.38) | RXRAPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8428613 | 0.65 | RXRA (0.37) | RXRAPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8431725 | 0.65 | RXRA (0.36) | RXRAPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8428373 | 0.65 | RXRA (0.39) | RXRAPPARGMEN1CYP1A2CYP3A4 | |
| SCHEMBL8428468 | 0.64 | MEN1 (0.39) | RXRAPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965619-A | ADMINISTERING AN INDENE DERIVATIVE OF GIVEN FORMULA, SUCH AS 1-(2,4,6-TRIMETHOXYBENZYLIDENE)-5-DIMETHYLAMINO-2-METHYL-3-INDENYL ACETIC ACID, TO TREAT PRECANCEROUS LESIONS SUCH AS COLONIC ADENOMATOUS POLYPS; SIDE EFFECT REDUCTION | CELL PATHWAYS INC. (US) | 1999-10-12 | — | — | US | disclosed |