Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 10/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430226 | 0.91 | PPARG (0.39) | RXRAPPARGPTGS1 | |
| SCHEMBL8430238 | 0.91 | MAOA (0.36) | RXRAPPARGPTGS1PSEN1PSEN2 | |
| SCHEMBL8432051 | 0.88 | PPARG (0.41) | RXRAPPARG | |
| SCHEMBL8430304 | 0.86 | MAPT (0.36) | — | |
| SCHEMBL25305567 | 0.74 | HTR6 (0.38) | PPARGPTGS1 | |
| SCHEMBL25308302 | 0.70 | HTR6 (0.36) | PPARGPTGS1 | |
| SCHEMBL8428613 | 0.68 | RXRA (0.37) | RXRAPPARGPTGS1PSEN1PSEN2 | |
| SCHEMBL8430782 | 0.67 | RXRA (0.38) | RXRAPPARGPTGS1PSEN1PSEN2 | |
| SCHEMBL6505678 | 0.67 | NR1H2 (0.41) | — | |
| SCHEMBL8428373 | 0.66 | RXRA (0.39) | RXRAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965619-A | ADMINISTERING AN INDENE DERIVATIVE OF GIVEN FORMULA, SUCH AS 1-(2,4,6-TRIMETHOXYBENZYLIDENE)-5-DIMETHYLAMINO-2-METHYL-3-INDENYL ACETIC ACID, TO TREAT PRECANCEROUS LESIONS SUCH AS COLONIC ADENOMATOUS POLYPS; SIDE EFFECT REDUCTION | CELL PATHWAYS INC. (US) | 1999-10-12 | — | — | US | disclosed |