Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 9/20 | 0.43 |
| ▸ | MMP3 | P08254 | 9/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7349860 | 1.00 | F2 (0.49) | F2F10PRSS1MMP1MMP3 | |
| SCHEMBL12494278 | 0.89 | F2 (0.48) | F2F10PRSS1MMP1MMP3 | |
| SCHEMBL17770856 | 0.89 | F2 (0.48) | F2F10PRSS1MMP1MMP3 | |
| SCHEMBL15130754 | 0.88 | F2 (0.51) | F2F10PRSS1MMP1MMP3 | |
| SCHEMBL3724402 | 0.88 | F2 (0.56) | F2F10PRSS1MMP1MMP3 | |
| SCHEMBL5640985 | 0.88 | F2 (0.56) | F2F10PRSS1MMP1MMP3 | |
| SCHEMBL7471624 | 0.86 | MMP1 (0.49) | F2F10PRSS1MMP1MMP3 | |
| SCHEMBL21165916 | 0.85 | F2 (0.53) | F2F10PRSS1MMP1MMP3 | |
| SCHEMBL15132431 | 0.85 | F2 (0.48) | F2F10PRSS1MMP1MMP3 | |
| SCHEMBL10265431 | 0.85 | F2 (0.48) | F2F10PRSS1MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012125622-A1 | SUBSTITUTED ADIPIC ACID AMIDES AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-09-20 | — | — | WO | disclosed |
| US-5859239-A | Mercaptoalkanoylamino and acylmercaptoalkanoylamino benzoxazepines and benzothiazepines | E. R. SQUIBB & SONS, INC. (US) | 1999-01-12 | — | — | US | disclosed |
| US-5856477-A | HYPOTENSIVE AGENTS; CONGESTIVE HEART FAILURE | E. R. SQUIBB & SONS, INC. (US) | 1999-01-05 | — | — | US | disclosed |
| US-5723602-A | ANGIOTENSIN CONVERTING ENZYME AND ENDOPEPTIDASE INHIBITORS, CARDIOVASCULAR DISORDERS | E. R. SQUIBB & SONS, INC. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5723457-A | COMPOUMDS FOR CARDIOVASCULAR DISORDERS AND INHIBITORS OF ANGIOTENSIN CONVERTING ENZYMES | E. R. SQUIBB & SONS, INC. (US) | 1998-03-03 | — | — | US | disclosed |