Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.43 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.43 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4359364 | 0.86 | PTGS2 (0.47) | PTGS2KDM4EPOLBKCNJ6KCNJ5 | |
| SCHEMBL8428544 | 0.85 | PTGS2 (0.46) | PTGS2KDM4EPOLBKCNJ6KCNJ5 | |
| SCHEMBL1030028 | 0.82 | KDM4E (0.46) | PTGS2KDM4EPOLBKCNJ6KCNJ5 | |
| SCHEMBL1030401 | 0.82 | BRD4 (0.45) | PTGS2KDM4EPOLBKCNJ6KCNJ5 | |
| SCHEMBL5809545 | 0.81 | PTGS2 (0.46) | PTGS2KDM4EPOLBKCNJ6KCNJ5 | |
| SCHEMBL4352690 | 0.81 | POLB (0.49) | PTGS2POLBKCNJ6KCNJ5KCNJ3 | |
| SCHEMBL17673290 | 0.81 | PTGS2 (0.48) | PTGS2KDM4EPOLBKCNJ6KCNJ5 | |
| SCHEMBL3322508 | 0.80 | LMNA (0.61) | PTGS2KDM4EPOLBGAALMNA | |
| SCHEMBL12402397 | 0.77 | PTGS2 (0.48) | PTGS2KDM4EPOLBKCNJ6KCNJ5 | |
| SCHEMBL1374365 | 0.77 | POLB (0.73) | PTGS2KDM4EPOLBGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859007-A | TREATMENT OF DIABETES, OBESITY | GLAXO WELLCOME INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0755384-A1 | CCK OR GASTRIN MODULATING 1,5 BENZODIAZEPINES DERIVATIVES | GLAXO WELLCOME INC. (US) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028391-A1 | CCK OR GASTRIN MODULATING 1,5 BENZODIAZEPINES DERIVATIVES | GLAXO WELLCOME INC. (US) | 1995-10-26 | — | — | WO | disclosed |