Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL8430748 | 1.00 | KDM4E (0.48) | KDM4ESMN1; SMN2SIGMAR1NPY2RHDAC4 | |
| SCHEMBL8430800 | 0.94 | KDM4E (0.53) | KDM4ESMN1; SMN2 | |
| SCHEMBL8430804 | 0.94 | KDM4E (0.53) | KDM4ESMN1; SMN2 | |
| SCHEMBL8128381 | 0.83 | SMN1; SMN2 (0.60) | KDM4ESMN1; SMN2SIGMAR1 | |
| SCHEMBL8128377 | 0.83 | SMN1; SMN2 (0.60) | KDM4ESMN1; SMN2SIGMAR1 | |
| SCHEMBL8429501 | 0.81 | KDM4E (0.64) | KDM4ESMN1; SMN2SIGMAR1 | |
| SCHEMBL8429503 | 0.81 | KDM4E (0.64) | KDM4ESMN1; SMN2SIGMAR1 | |
| SCHEMBL8429465 | 0.81 | KDM4E (0.60) | KDM4ESMN1; SMN2 | |
| SCHEMBL8429460 | 0.81 | KDM4E (0.60) | KDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8428835 | 0.80 | KDM4E (0.66) | KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861407-A | Tetrahydropyridine derivatives as dopamine receptor subtype ligands | MERCK SHARP & DOHME, LTD. (GB) | 1999-01-19 | — | — | US | disclosed |